Anti-Cytokeratin 5 antibody [XM26] (ab17130) (2024)

Overview

• Product name

  Anti-Cytokeratin 5 antibody [XM26]
  See all Cytokeratin 5 primary antibodies

• Description

  Mouse monoclonal [XM26] to Cytokeratin 5

• Host species

  Mouse

• Tested applications

  Suitable for: IHC-P, Flow Cytmore details

• Species reactivity

  Reacts with: Human
  

  See Also

  Best tax saving mutual funds or ELSS to invest in June 20245-Fluorocytosine (5-FC), antifungal agent (CAS 2022-85-7) (ab141197)Medibank legal case a 'wake-up' call for Australian businessesCho tam giác ABC. Trong tam giác lấy một điểm M sao cho góc MAC= góc MBC. Kẻ ME, MF lần lượt vuông góc với BC, AC. Gọi D là trung điểm AB. Chứng minh rằng DE=DF

• Immunogen

  Prokaryotic recombinant protein corresponding to 103 amino acid portion of the C-terminal region of the cytokeratin 5 molecule (Human).

• Positive control

  • Skin

• General notes

  The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

  If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

• Form

  Liquid

• Storage instructions

  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

• Storage buffer

  pH: 7.3
  Preservative: 0.05% Sodium azide
  Constituents: Tissue culture supernatant, 1% BSA

• Concentration information loading...

• Purity

  Tissue culture supernatant

• Clonality

  Monoclonal

• Clone number

  XM26

• Isotype

  IgG1

• Light chain type

  kappa

• Research areas

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Intermediate Filaments
  • Class I
  • Cytokeratins

Associated products

• Compatible Secondaries

• Isotype control

  • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Mouse IgG1, Kappa Monoclonal [B11/6] - Isotype Control (ab91353)

• Recombinant Protein

  • Recombinant Human Cytokeratin 5 protein (ab132931)

Applications

Target

• Involvement in disease

  Defects in KRT5 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
  Defects in KRT5 are the cause of epidermolysis bullosa simplex with migratory circinate erythema (EBSMCE) [MIM:609352]. EBSMCE is a form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, and legs but spare nails, ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.
  Defects in KRT5 are a cause of epidermolysis bullosa simplex Weber-co*ckayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
  Defects in KRT5 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, althought it is less severe.
  Defects in KRT5 are the cause of epidermolysis bullosa simplex with mottled pigmentation (MP-EBS) [MIM:131960]. MP-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and 'mottled' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
  Defects in KRT5 are the cause of Dowling-Degos disease (DDD) [MIM:179850]; also known as Dowling-Degos-Kitamura disease or reticulate acropigmentation of Kitamura. DDD is an autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.

• Sequence similarities

  Belongs to the intermediate filament family.

• Information by UniProt

• Database links

  • Entrez Gene: 3852 Human
  • Omim: 148040 Human
  • SwissProt: P13647 Human
  • Unigene: 433845 Human

• Alternative names

  • 58 kDa cytokeratin antibody
  • CK-5 antibody
  • CK5 antibody

  see all

Images

Protocols

Datasheets and documents

References (13)